Hello to all
For your information, with all ticket sales, auction etc and then the costs taken out etc. Angelina Our Star Appeal made: a Total for the Ball Event: £4,307.07
The plan is to hand over a further cheque for £6,000.00 to Great Ormond Street and to give the PCN nurses based in Southend who helped Angelina so Very much £1,000.00.
So all in all we would have handed to Great Ormond Street £26,000 and £6,000, totalling: £32,000.00 from a local Appeal.
This would not have happened without all Your Help and Support towards the Appeal - So Thank You Very Very much.
I do hope the money raised will help so many children and the research towards Wilms.
The Appeal will stay active and I plan to hold other events in the near future.
I will keep you updated on when we present the Cheques to Great Ormond Street and the PCN Team.
Thank you again. Best Wishes With Love, Hilary Vidler
www.angelinaourstar.org.uk
ANGELINA OUR STAR APPEAL BALL Friday 7 October 2011 at The Lawn
I would like to Thank Everyone who attended and Supported the Evening.
What a Wonderful Night.
Thank you so very much.
Kathy Pritchard-Jones and John Andersen attended and Supported the Evening.
Some wonderful items were Donated and Auctioned.
A Fantastic Amount was Raised - c.£4,000.00
The Appeal Team look forward to presenting this to GOSH and the PCN Nurses very soon.
*****THANK YOU*THANK YOU*THANK YOU*****
On Tuesday 7th December 2010, Members of the Appeal Committee presented a cheque to Professor Pritchard-Jones for £26,000 towards her research work on Wilms Tumour.
Thank you to everyone who has donated to the Angelina Our Star Appeal.
Further donations to the Appeal will benefit the "Kiss it Better" Campaign which helps fund clinical trials into Childhood Cancers.
Please continue to support the Appeal.
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Here is a link to a recent press release that was issued by Cancer Research UK about the work that Professor Kathy Pritchard-Jones and her group are doing.
http://info.cancerresearchuk.org/news/archive/pressrelease/2010-04-02
Below is some information from Dr. Richard Williams, Senior Scientist in the group, about what they are doing and some of the costs involved:
We use 'Affymetrix SNP Arrays' in our work. These are 'DNA chips' that give us a high resolution view of the damaging changes to the human genome that often occur in cancer cells. The current cost of running one of these chips is £275 per sample, but this gives us a great deal of data for each tumour we analyse (and each contributes to our overall knowledge of Wilms tumour). We have used this technique to identify two types of DNA damage that occur in some Wilms tumours - loss of one gene (FBXW7) and extra copies of another (MYCN):
We believe that identifying changes like this will lead to new tests that help us choose the right level of treatment for individual children, preventing recurrence of the tumour without giving the patients more toxic chemotherapy than they need. In the longer term, it may lead to new treatments for those children who don't respond well to any of the current therapies.
We have collected hundreds of Wilms tumour samples that could be analysed on the Affymetrix chips if resources permitted (104 have been successfully analysed so far). In the short term, we hope to extend our earlier work by analysing an additional 30-50 tumours of particular interest (£8,250-£13,750). We've also recently started to use an exciting new technique called 'exome sequencing'. This is much more expensive (£3,200 per patient), but gives us a lot more information. Using this technique, we can potentially read the 'coding sequence' ('letters' of the DNA alphabet) of all known human genes in a single tumour at once. By comparing these gene sequences with those in normal DNA collected from the same patient's blood cells, we can look directly for tiny changes found only in the tumour, down to the level of a single mistake (mutation) in an individual DNA 'letter'. Although we'd love to apply this powerful technique to a large number of tumours, the high cost means we'd probably have to limit the analysis to a selected series; a group of 5 would cost £16,000, though ideally we'd do at least 12 (£38,400).
